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PF-562271

PF-562271结构式

规格 价格 库存状态
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质量管理及说明

  • 当前批次:
  • HPLC>98%     产品COA和检测报告随货发出
  • 1生物活性

    Filgotinib (GLPG0634) is an orally-available, selective inhibitor of JAK1 (Janus kinase 1) for the treatment of rheumatoid arthritis and potentially other inflammatory diseases. Filgotinib (GLPG0634) dose-dependently inhibited Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro. GLPG0634 was well exposed in rodents upon oral dosing, and exposure levels correlated with repression of Mx2 expression in leukocytes. The JAK1 selective inhibitor GLPG0634 (Filgotinib) is a promising novel therapeutic with potential for oral treatment of rheumatoid arthritis and possibly other immune-inflammatory diseases. Filgotinib (GLPG0634) is currently in a Phase 2 study in Crohn's disease.


    化学数据

    分子量 425.5
    分子式 C21H23N5O3S
    CAS号 1206161-97-8
    纯度 98.32%
    溶解性(25°C) DMSO
    储存和运输条件 -20°C 冷藏长期储存
    常温运输及临时存放
     

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